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Weight Loss / MetabolicInjectableResearch Protocol

Semaglutide Dosage Chart

Semaglutide is a long-acting GLP-1 receptor agonist extensively studied for glycemic control and body composition. Once-weekly subcutaneous administration is standard.

AI-built tool. Cross-check critical values against authoritative sources before use.

Half-life

~7 days

Format

Injectable

Purity

≥99%

Protocols

4 variants

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Research Protocols

Dosage Protocols

Each row reflects a common research protocol variant. These are reference ranges derived from published literature and community research — not medical guidance.

Protocol 1

Titration Phase (Weeks 1-4)

4 weeks

Dose

0.25mg once weekly

Duration

4 weeks

Starting dose from published trial protocols. Minimizes initial GI adaptation effects.

Protocol 2

Escalation Phase (Weeks 5-8)

4 weeks

Dose

0.5mg once weekly

Duration

4 weeks

Second titration step. Hold here if tolerance is mixed before moving to higher doses.

Protocol 3

Standard Research Protocol

8-16 weeks

Dose

1.0mg once weekly

Duration

8-16 weeks

Core maintenance research dose. Balances effect and tolerability in most protocols.

Protocol 4

Elevated Research Protocol

8-16 weeks

Dose

2.0-2.4mg once weekly

Duration

8-16 weeks

High-dose variant used in obesity-specific trials. Reach only after successful titration through lower doses.

Mixing Math

Reconstitution

Reference values for preparing a research vial. Adjust the syringe reading if you change the water volume.

Vial size

5mg vial

BAC water

2ml bacteriostatic water

Concentration

2.5mg/ml

Dose / ml

0.25mg = 0.1ml · 1mg = 0.4ml

Syringe units

10 IU (0.25mg) · 40 IU (1mg) on U-100

Need help converting different vial sizes? Use our reconstitution calculator to generate protocol-specific numbers instantly.

Storage

Handling Notes

Lyophilized: -20°C long-term, 2-8°C for short-term. Reconstituted: refrigerate at 2-8°C and use within 28 days. Do not shake vigorously.

Research Considerations

Cautions

  • GLP-1 agonists can cause significant GI adaptation — slow titration is essential.
  • Monitor hydration, electrolytes, and lean-mass markers throughout research.
  • Not suited for mass-gain research phases; caloric reduction is a primary effect.

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Research use only. Not medical advice. Browse all dosage charts