Research Journal
Peptide research, explained.
Daily field notes on compounds, protocols, and the science behind them. No hype, no filler — just the research distilled.
Semaglutide for Alcohol Cravings: What the 2025 Research Shows
A 2025 JAMA Psychiatry RCT found semaglutide cut alcohol intake and weekly cravings in adults with AUD. Here is the full 2026 GLP-1 alcohol research read.
Nasal Peptides in 2026: Which Work, Which Don't
Nasal peptide bioavailability spans under 1% to near 30%. Here is what the 2026 clinical research shows about oxytocin, PT-141, Selank, Semax, and DSIP.
GLP-1 Muscle Loss: What the Research Shows in 2026
Semaglutide and tirzepatide trials put lean mass loss at 25-40% of total weight lost. Here is what the research says about preserving muscle on GLP-1 therapy.
Tesamorelin: The FDA-Approved GHRH Analog for Visceral Fat
Tesamorelin cut visceral fat 15.2% in 412 patients over 26 weeks. Here is what the GHRH analog does, how it compares to GLP-1s, and what safety shows.
MOTS-c: The Mitochondrial Peptide That Mimics Exercise
MOTS-c doubled running capacity in old mice and improved insulin sensitivity by 30%. Here is what the research shows about this mitochondrial-derived exercise mimetic.
MK-677: The Oral GH Secretagogue That Replaced My Injection Ritual
MK-677 (ibutamoren) is not a peptide. It is an oral ghrelin mimetic with a 24-hour half-life, real clinical data, and trade-offs you need to understand before starting.
PT-141 (Bremelanotide): The Only FDA-Approved Peptide for Sexual Function
Bremelanotide works in the brain, not the blood vessels. Here is everything the research shows about the melanocortin peptide that treats desire itself, not just the plumbing.
SS-31 (Elamipretide): FDA-Approved Mitochondrial Peptide Guide
SS-31 (elamipretide) became the first mitochondrial peptide with FDA approval in 2025. Here are the clinical trial results for aging, vision, and muscle.
Thymosin Alpha-1: The Most Tested Immune Peptide You Never Heard Of
Thymosin alpha-1 has 30+ clinical trials across 11,000 subjects and is approved in 35 countries. Here is what the data actually shows for immune function.
Calm + Clarity: The Cognitive Stack for Focus Without the Fog
Three peptides, three distinct CNS pathways. How Selank, Pinealon, and PE 22-28 combine GABA modulation, neuroprotection, and TREK-1 channel activity into a single cognitive protocol.
GLOW Blend: The Complete Recovery + Skin Protocol
GHK-Cu turns the Wolverine Stack into a three-compound skin and recovery powerhouse. Here's how collagen synthesis, angiogenesis, and cell migration work together, and the protocol to run it.
KLOW Blend: 4-Peptide Skin, Gut, and Recovery Protocol
What happens when you add KPV's NF-kB inhibition to the GLOW stack. The gut-skin axis, IBD research, and the case for a four-compound protocol.
CagriSema: Cagrilintide + Semaglutide REDEFINE 1 Results
CagriSema delivered 20.4% weight loss at 68 weeks in REDEFINE 1. Here is what cagrilintide does and how the phase 3 data stacks up against tirzepatide.
The Wolverine Stack: BPC-157 + TB-500 Recovery Protocol
The two most-researched recovery peptides in a single vial. How BPC-157 and TB-500 complement each other mechanistically, practical dosing protocols, reconstitution math, and week-by-week expectations.
The FIT Stack: CJC-1295 + Ipamorelin GH Protocol
The gold standard GHRH + GHRP pairing for natural growth hormone optimization. Receptor-level synergy, practical dosing around sleep and fasting windows, reconstitution math, and realistic timelines.
Injectable vs Oral Peptides: Bioavailability and What Matters
Oral capsules are convenient. Injectables are cheaper per dose. But bioavailability is only half the story. A compound-by-compound breakdown of which format serves which research goal.
The Enhanced Games: What the Peptide Community Needs to Know
A $1.2 billion sporting event where athletes openly use BPC-157, CJC-1295, and testosterone. Here is everything we know about the Enhanced Games heading into May 2026.
Retatrutide vs Tirzepatide vs Semaglutide: 2026 GLP-1 Comparison
Three receptor agonists. Three weight loss profiles. A head-to-head on efficacy, side effects, half-life, and dose, with the 2026 trial data.
12-Week Retatrutide Titration Protocol: Research Dose Schedule
Mirrors the Phase 2 dose ladder to minimize GI side effects during escalation. Weekly targets, reconstitution math, and what trial data shows at each step.
BPC-157 vs TB-500: Which Recovery Peptide Actually Works?
Both are touted for tissue repair, but the mechanisms and use cases are completely different. Here's when to use each, and when to stack them.
Tirzepatide vs Semaglutide: The 2026 Head-to-Head
The two most-studied GLP-1 compounds compared across weight reduction, glycemic control, and side effect profiles. Which one wins depends on your research question.
CJC-1295 + Ipamorelin Stack: The Complete GH Research Protocol
Why pairing a GHRH with a GHRP produces more growth hormone than either alone, and the exact protocol the research community uses.
NAD+ Injection Protocol: Dosing, Timing, and What the Research Shows
The coenzyme behind Huberman, Sinclair, and Attia's longevity protocols. How researchers dose injectable NAD+ and what to expect.
BPC-157 Dosing Protocols: A Researcher's Complete Guide
How much, how often, where to inject, and what the literature actually supports. The definitive BPC-157 dosing reference for research.
Retatrutide Explained: Why It's the Most Effective Weight Peptide Yet
Retatrutide hit Phase 3: 28.7% weight loss at 12 mg over 68 weeks in TRIUMPH-4. Here is the verified mechanism, current trial readouts, and what is still missing.
Peptide Reconstitution: The Complete Guide
BAC water, concentration math, syringe units, storage. Everything you need to know about reconstituting lyophilized peptides for research.
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