TRT · Hub
TRT, without the clinic markup
The medication costs about fifty dollars a year. Everything above that is service. Start with the dose math almost nobody explains properly, then read what the trials actually found.
The mg to mL to units converter
“1 mL a week” is the most common way people describe their protocol, and it is meaningless on its own. At 100 mg/mL it is 100 mg. At 250 mg/mL it is 250 mg. Same syringe, two and a half times the drug.
Dossier · Inputs
Configure the protocol
Read the concentration off your vial label first. It is the number everything else depends on.
Ester
The US default. Long enough for weekly, smoother split twice weekly.
Vial concentration
Printed on the label as mg/mL. This is what makes 1 mL ambiguous.
Injections per week
Injecting every 3.5 days on a 8-day half-life keeps levels steady.
Syringe
Vial size
Draw per injection
50.0 mg = 0.250 mL
on a U-100 insulin (1 mL)
Dose band
Typical replacement window
The 125 mg arm averaged 542 ng/dL, squarely mid-normal. This is the usual clinical target zone.
Weekly volume
Vial lasts
10 mL @ 200 mg/mL
Dose bands reference the published arm means from Bhasin et al., Am J Physiol Endocrinol Metab 2001 (PMID 11701431), where endogenous production was suppressed with a GnRH agonist so achieved levels map cleanly onto dose. They describe what happened in that trial, not what will happen to you.
Start here
The four questions everyone asks first
TRT Cost in 2026: What You Actually Pay, Line by Line
The drug costs about $50 a year. Everything else is the clinic. Here is the honest breakdown of TRT pricing with and without insurance in 2026.
8 min read
Is 1 mL of Testosterone a Week Enough? The mg-to-mL Math
One mL means nothing without concentration. It could be 100 mg or 250 mg. Here is the dose math and the human dose-response data behind it.
8 min read
Is TRT a Steroid? Yes. That Is Not the Useful Question.
Testosterone is an anabolic androgenic steroid and a Schedule III controlled substance. The distinction that matters is dose, and the data is specific.
8 min read
TRT Before and After: What Actually Changes, and When
Libido moves at 3 weeks. Fat and muscle take 12 to 16. Red blood cells peak at a year. The measured timeline of testosterone therapy, week by week.
8 min read
Restoration, not replacement
Raising your own production instead
Exogenous testosterone suppresses LH and FSH, and testicular volume and sperm production follow. For men with an intact axis, especially younger men with secondary hypogonadism, the HPG-axis compounds are the conversation worth having first.
Peptides for Testosterone: Which Ones Actually Raise It
Most peptides sold for testosterone act on the growth hormone axis and never touch it. Only three hit the HPG axis. Here is what the human data shows.
8 min read
HCG vs Gonadorelin: Preserving Fertility and Testicular Function on TRT
HCG mimics LH at the testicle; gonadorelin signals the pituitary and must be pulsed. Which one actually protects fertility and testicular size on TRT, and why.
11 min read
Gonadorelin for TRT in 2026: What the GnRH Evidence Actually Shows
Gonadorelin is GnRH. The pulsatile-pump trial evidence is real. The twice-daily TRT-adjunct protocol popular at telehealth clinics has zero RCTs behind it.
14 min read
Kisspeptin in Humans: Libido, Fertility, and HPG Axis Research
Imperial College trials show kisspeptin boosts sexual brain processing and penile rigidity by 56%. Here is the full kisspeptin human evidence read for 2026.
13 min read
Compounds
The three that actually touch the axis
HCG (Human Chorionic Gonadotropin)
LH-mimetic hormone studied for preserving testicular function and fertility during testosterone therapy
Open guide →
Gonadorelin
Synthetic GnRH (LHRH) studied for pituitary stimulation, fertility, and as a TRT fertility-preservation adjunct
Open guide →
Kisspeptin
Master hormone switch for reproductive and HPG axis research
Open guide →
Sourcing
Kisspeptin-10, gonadorelin, and hCG
Every number on this page assumes the vial contains what the label says. Check the batch certificate before you dose anything, then source deliberately.
Available from Ascension Peptides with 50% off using code ENHANCED.
Related tools
TRT dose math, explained
Is 1 mL of testosterone a week enough?+
The question cannot be answered as asked, because 1 mL is a volume rather than a dose. Testosterone cypionate is sold at 100 mg/mL and 200 mg/mL, and compounding pharmacies fill 250 mg/mL, so 1 mL weekly is anywhere from 100 mg to 250 mg. Read the concentration printed on your vial, then use the calculator above to convert it into milligrams.
How do I convert testosterone mg to syringe units?+
Divide your target dose in milligrams by the vial concentration in mg/mL to get the volume in mL. On a U-100 insulin syringe, 1 mL equals 100 units, so a 0.25 mL draw reads as 25 units. At 200 mg/mL, a 50 mg injection is 0.25 mL, which is 25 units.
What is a normal weekly TRT dose?+
Clinical replacement most often lands near 100 to 125 mg weekly. In a controlled dose-response trial where endogenous production was suppressed, 125 mg weekly produced a mean total testosterone of 542 ng/dL, squarely mid-normal, while 25 and 50 mg weekly produced 253 and 306 ng/dL. Doses above 200 mg weekly are no longer replacement.
Should I split my weekly testosterone into two injections?+
Splitting the same weekly total across two injections narrows the peak-to-trough swing without changing the weekly milligrams. Testosterone cypionate and enanthate have half-lives of roughly 8 and 4.5 days, so a single weekly injection produces a noticeable peak and trough that twice-weekly dosing flattens.
Is this calculator medical advice?+
No. It is a dosing-math tool that converts between milligrams, millilitres, and syringe units using numbers you enter. It does not recommend a dose. Testosterone is a Schedule III controlled substance in the United States and requires a prescription and clinical monitoring.
This page is for informational and educational purposes only and is not medical advice. Testosterone is a Schedule III controlled substance in the United States and requires a prescription. Kisspeptin-10 and gonadorelin are research chemicals not approved for human use. Consult a licensed physician regarding diagnosis, treatment, and monitoring.