AOD-9604
Modified hGH fragment (177-191) researched for lipolytic activity without growth effects
Half-life
~30 min
Typical Dose
300 mcg daily SC
Format
Injectable
Purity
≥98%
Overview
AOD-9604 is a synthetic analog of the C-terminal fragment (amino acids 177-191) of human growth hormone, engineered to replicate the lipolytic (fat-burning) effects of hGH without the growth-promoting or insulin-antagonistic effects. It was originally developed in the 1990s at Monash University in Australia as an anti-obesity candidate. It has since been studied for obesity, osteoarthritis, and broader metabolic research applications.
Mechanism
Stimulates lipolysis and inhibits lipogenesis in adipocytes without affecting IGF-1 production or insulin sensitivity. Acts primarily through the beta-3 adrenergic receptor pathway in adipose tissue, mimicking the fat-mobilizing C-terminus of hGH while lacking the receptor affinity responsible for growth effects.
Researched benefits
- Selective lipolysis in adipose tissue
- No appetite suppression
- No effect on blood glucose or IGF-1
- Compatible with GLP-1 and GH protocols
- Minimal side effect profile in studies
- No growth-promoting activity
Frequently asked
How is AOD-9604 different from full hGH?
AOD-9604 is a fragment covering only amino acids 177-191 of hGH — the lipolytic 'tail' — with a tyrosine added at the N-terminus for stability. It retains the fat-mobilizing effects but lacks the receptor-binding regions responsible for growth, insulin antagonism, and IGF-1 elevation.
Does AOD-9604 affect blood glucose or IGF-1?
Unlike full hGH, published studies indicate AOD-9604 does not raise IGF-1, does not impair glucose tolerance, and does not produce the insulin-antagonistic effects of growth hormone. This is why it was pursued as a selective anti-obesity candidate.
Can AOD-9604 be stacked with GLP-1 peptides?
Researchers commonly investigate AOD-9604 alongside Semaglutide, Tirzepatide, or Retatrutide. The mechanisms are complementary: GLP-1 agonists reduce caloric intake via central appetite pathways, while AOD-9604 directly mobilizes fat from adipocytes without affecting satiety.
How is AOD-9604 reconstituted?
Bacteriostatic water is the standard diluent. For a 5mg vial, 2.5mL of BAC water yields 2mg/mL (so 300 mcg = 0.15mL). Swirl gently, refrigerate after reconstitution, and use within 14-30 days.
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