Kisspeptin
Master hormone switch for reproductive and HPG axis research
Half-life
~30 min
Typical Dose
Research-dependent
Format
Injectable
Purity
≥98%
Overview
Kisspeptin is the upstream regulator of the HPG (hypothalamic-pituitary-gonadal) axis. Studied for reproductive function, fertility, and as a research tool for hormonal modulation.
Sequence & properties
Sequence, colored by side chain
Length
10 aa
Avg mass
1,303.4 Da
Theoretical pI
9.35
Net charge (pH 7)
+1.0
Mechanism
Acts on KISS1R (GPR54) receptors in the hypothalamus to stimulate GnRH release, which then triggers LH and FSH release from the pituitary.
Researched benefits
- GnRH stimulation
- Fertility research
- Testosterone modulation studies
- HPG axis research
Frequently asked
What does kisspeptin do?
Kisspeptin is the product of the KISS1 gene and sits upstream of the reproductive axis. It stimulates GnRH neurons in the hypothalamus, which in turn drives LH and FSH release. It is the gatekeeper of the HPG axis.
Kisspeptin-10 vs kisspeptin-54?
Both are fragments of the parent peptide. Kisspeptin-10 is the shorter active core with a very short half-life; kisspeptin-54 is longer-acting. The choice in research protocols depends on whether a pulse or sustained exposure is wanted.
Why is kisspeptin studied for libido?
Imaging work has reported that kisspeptin administration modulates activity in brain regions tied to sexual and emotional processing, separate from its hormonal effects on LH. This central action is the basis for the research interest.
What is kisspeptin's half-life?
Kisspeptin-10 clears in minutes, which is why continuous infusion or the longer kisspeptin-54 fragment is used in studies requiring sustained receptor engagement.
Ready to start your research
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