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Melanocortin / TanningInjectableResearch Protocol

Melanotan II (MT-2) Dosage Chart

Melanotan II is a synthetic cyclic melanocortin agonist that activates MC1R (skin pigmentation) plus MC3R, MC4R, and MC5R. It is studied for melanogenesis and, via MC4R, for appetite and sexual arousal. Research protocols use a low-dose loading phase to build pigmentation, then intermittent maintenance. Note the strong side-effect profile and the serious melanoma-monitoring caution below before anything else.

AI-built tool. Cross-check critical values against authoritative sources before use.

Half-life

~1-2 hours

Format

Injectable

Purity

≥98%

Protocols

3 variants

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Research Protocols

Dosage Protocols

Each row reflects a common research protocol variant. These are reference ranges derived from published literature and community research — not medical guidance.

Protocol 1

Loading Protocol

1-2 weeks, or until target pigmentation

Dose

0.25mg subcutaneous once daily, building toward 0.5mg

Duration

1-2 weeks, or until target pigmentation

Start low. The 0.25mg entry dose limits the nausea and flushing that hit hardest early. Pigmentation develops with UV exposure, so it is studied alongside measured sun or UV, not as a replacement for it.

Protocol 2

Maintenance Protocol

As needed to maintain pigmentation

Dose

0.5-1mg subcutaneous, 2-3x per week

Duration

As needed to maintain pigmentation

Once target pigmentation is reached, frequency drops to intermittent dosing. More frequent dosing mostly adds side effects, not more tan.

Protocol 3

MC4R Overlap Note

n/a

Dose

Same doses as above

Duration

n/a

MT-2's MC4R activity is why spontaneous erections and appetite suppression occur. The refined MC4R-focused derivative studied for sexual health is PT-141 (bremelanotide); see its chart for that endpoint.

Mixing Math

Reconstitution

Reference values for preparing a research vial. Adjust the syringe reading if you change the water volume.

Vial size

10mg vial

BAC water

2ml bacteriostatic water

Concentration

5mg/ml

Dose / ml

0.25mg = 0.05ml · 0.5mg = 0.1ml

Syringe units

5 IU (0.25mg) · 10 IU (0.5mg) on a U-100 syringe

Need help converting different vial sizes? Use our reconstitution calculator to generate protocol-specific numbers instantly.

Storage

Handling Notes

Lyophilized: -20°C long-term, 2-8°C short-term. Reconstituted with bacteriostatic water: refrigerate at 2-8°C and use within about 21-28 days. Swirl gently, never shake, and do not freeze the reconstituted solution.

Research Considerations

Cautions

  • MELANOMA / MOLE MONITORING: MT-2 stimulates melanocytes and is linked in case reports to darkening moles, new or changing nevi, and melanoma. Get a baseline skin exam and see a dermatologist for any changing lesion. This is the single most important caution.
  • Common early effects: nausea, facial flushing, appetite suppression, and spontaneous erections (MC4R). These are dose-dependent and heaviest during loading.
  • Blood-pressure and heart-rate changes have been reported with central melanocortin activation.
  • Melanotan II is not approved for human use in any jurisdiction. It is a research compound; source only COA-verified material.

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Research use only. Not medical advice. Browse all dosage charts