GHRP-6

GHRP-6 is a functional ghrelin mimetic. It activates GHS-R1a on NPY/AgRP neurons in the hypothalamic arcuate nucleus, the same orexigenic pathway the body's hunger hormone uses. Hunger typically hits within 20-30 minutes of injection and is far more pronounced than with GHRP-2 or Ipamorelin. Whether this is useful or limiting depends entirely on the research goal.

All three are GHS-R1a agonists that release GH. GHRP-6 produces the strongest appetite response and can nudge cortisol and prolactin at higher doses. GHRP-2 releases somewhat more GH with less hunger. Ipamorelin is the most selective, with minimal hunger, cortisol, or prolactin effect. GHRP-6 is generally chosen when appetite stimulation is part of the research question.

Around 100mcg per dose is the common reference point, since the GH response tends to saturate near that level. Protocols run 100-200mcg subcutaneously, 1-3x daily, often pre-bed, post-workout, or fasted. Pushing the dose higher raises cortisol and prolactin more than it raises GH, so larger amounts offer diminishing returns.

This is the standard research pairing. GHRP-6 acts on the ghrelin receptor while CJC-1295 (or Sermorelin) acts on the GHRH receptor. Because the two receptors act in synergy, the combined GH pulse is larger than either compound produces alone. A common approach is 100mcg of each dosed together.

Yes. Elevated blood glucose and free fatty acids blunt the GH response, so research protocols dose on an empty stomach and wait roughly 2 hours around meals, especially those high in carbohydrate or fat. This is one reason pre-bed and fasted-morning timing are common.

Bacteriostatic water is the standard diluent. For a 5mg vial, 2.5mL of BAC water yields 2mg/mL, so 100mcg sits in 0.05mL. Add the water slowly down the vial wall, swirl gently, never shake, then refrigerate and protect from light.