MK-677 (Ibutamoren)Research guide
Oral ghrelin mimetic for sustained GH and IGF-1 elevation
Half-life
~24 hours
Typical Dose
10-25mg daily
Format
Oral
Purity
≥98%
Overview
MK-677, also known as Ibutamoren, is an orally active ghrelin receptor agonist that produces sustained increases in GH and IGF-1. Unique among growth hormone secretagogues for its oral bioavailability.
Mechanism
Orally active ghrelin receptor agonist that mimics ghrelin's GH-releasing action with a long half-life suitable for once-daily dosing.
Researched benefits
- Oral administration (no injections)
- Sustained 24h GH elevation
- Increased lean mass
- Improved sleep quality
- Increased appetite
Frequently asked
Is MK-677 a peptide?
No. MK-677 (ibutamoren) is a non-peptide small molecule that mimics ghrelin at the GHS-R1a receptor. It is grouped with growth hormone secretagogues by function, not by structure, and unlike the peptide secretagogues it survives digestion.
Why is MK-677 taken orally?
Its small-molecule structure resists gastric breakdown, giving it oral bioavailability that peptide secretagogues such as ipamorelin lack. This is the practical reason it appears in protocols where injection is undesirable.
Why does MK-677 cause water retention and appetite increase?
Both follow from the mechanism. Ghrelin receptor agonism drives hunger directly, and elevated GH and IGF-1 promote sodium and fluid retention. These are the two most consistently reported effects in the literature.
What is MK-677's half-life?
Approximately 24 hours, which supports once-daily administration and produces sustained elevation of GH and IGF-1 rather than the pulsatile pattern seen with short-acting peptide secretagogues.
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Protocol
MK-677 (Ibutamoren) dosage chart
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