Ipamorelin
Selective growth hormone secretagogue with minimal cortisol impact
Half-life
~2 hours
Typical Dose
200-300mcg per dose
Format
Injectable
Purity
≥98%
Overview
Ipamorelin is a pentapeptide GHRP that selectively stimulates growth hormone release without significantly affecting cortisol or prolactin. Often combined with CJC-1295 for stacked effects.
Mechanism
Selective ghrelin/GHS-R agonist that triggers GH release from the pituitary without the side effects of older GHRPs.
Researched benefits
- Selective GH release
- No cortisol elevation
- Improved sleep and recovery
- Lean body mass support
- Well-tolerated profile
FIT Stack
CJC-1295 + Ipamorelin 10mg — the classic GH optimization stack
Partner price
$149.99
- GHRH + GHRP in one vial
- Validated synergistic ratio
- Same-day US shipping · COA verified
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Frequently asked
What makes ipamorelin selective?
Ipamorelin is a pentapeptide growth hormone secretagogue that binds the ghrelin receptor (GHS-R1a) with minimal effect on cortisol, prolactin, or ACTH. GHRP-6 and GHRP-2 stimulate those hormones more strongly, which is why ipamorelin is described as the cleaner secretagogue in the class.
Why is ipamorelin combined with CJC-1295?
The two act on separate receptors. CJC-1295 is a GHRH analog that raises the amplitude of GH pulses; ipamorelin acts through the ghrelin receptor and also suppresses somatostatin. Researchers pair them because GHRH plus a secretagogue produces a larger release than either alone.
Does ipamorelin increase appetite?
Far less than GHRP-6. Both bind GHS-R1a, but ipamorelin's weaker ghrelin mimicry means the hunger signal is substantially reduced. This is one of the main reasons it is chosen over GHRP-6 in research protocols.
What is ipamorelin's half-life?
Roughly two hours, which is why protocols typically use multiple daily administrations timed to preserve the natural pulsatile pattern of GH release rather than producing sustained elevation.
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