Selank
Russian nootropic peptide for anxiety, focus, and cognitive enhancement
Half-life
~30 min (intranasal)
Typical Dose
250-500mcg intranasal
Format
Nasal
Purity
≥98%
Overview
Selank is a synthetic analog of the natural peptide Tuftsin, developed in Russia for anxiety and cognitive disorders. Used as a nasal spray for cognitive enhancement and anxiolytic research.
Sequence & properties
Sequence, colored by side chain
Length
7 aa
Avg mass
751.9 Da
Theoretical pI
11.65
Net charge (pH 7)
+2.0
Mechanism
Modulates GABA, serotonin, and dopamine systems. Increases BDNF expression and influences enkephalin levels in the brain.
Researched benefits
- Anxiolytic effects
- Improved focus and memory
- Stress resilience
- BDNF modulation
- Non-sedating
Frequently asked
What is selank?
Selank is a synthetic heptapeptide developed at the Institute of Molecular Genetics in Russia. It is based on tuftsin, an immunomodulatory tetrapeptide, with a proline-glycine-proline tail added for stability.
Why is selank described as non-sedating?
Unlike benzodiazepines, selank does not act as a direct GABA-A agonist. Research points to modulation of GABAergic and serotonergic signaling plus effects on enkephalin degradation, which is the proposed basis for anxiolytic activity without sedation.
Selank vs semax?
Both come from the same Russian peptide research program and are usually delivered intranasally, but they target different things. Selank is studied for anxiolytic effects; semax is studied for cognition, attention, and neuroprotection.
Why is selank given intranasally?
Nasal administration is used to exploit the nose-to-brain route, which allows a peptide to reach the central nervous system without surviving first-pass metabolism. The peptide is not orally bioavailable.
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