Dihexa
HGF-mimetic peptide studied for synaptogenesis and cognitive enhancement
Half-life
~10 hours
Typical Dose
8-45mg daily
Format
Oral
Purity
≥98%
Overview
Dihexa is a small molecule derived from angiotensin IV that mimics hepatocyte growth factor. Studied for its potent effects on synaptogenesis and cognitive function in neurodegenerative research.
Mechanism
HGF-mimetic that activates the c-Met receptor, promoting synapse formation and neural plasticity. Crosses the blood-brain barrier.
Researched benefits
- Synaptogenesis promotion
- Memory enhancement in studies
- Neuroprotection
- Oral bioavailability
- Alzheimer's research
Frequently asked
What is dihexa?
Dihexa is a small-molecule derivative of angiotensin IV developed at Washington State University. It is not a classical peptide therapeutic but an oligopeptide-derived compound designed to cross the blood-brain barrier.
How does dihexa work?
Research points to potentiation of hepatocyte growth factor signaling through its receptor c-Met, which drives synaptogenesis. This is a different mechanism from the nootropic peptides that act on BDNF or neurotransmitter systems.
What is dihexa's research status?
Preclinical. The published work is rodent and cell-culture data from the original academic group. There are no completed human clinical trials, and the long-term safety profile is uncharacterized.
Why is dihexa described as orally active?
Its structure was specifically engineered for metabolic stability and blood-brain barrier penetration, unlike the injectable or intranasal peptides in the cognitive category. This was a design goal of the original research.
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