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Sermorelin

GHRH analog (1-29) for natural growth hormone stimulation

Half-life

~10-20 min

Typical Dose

100-500mcg before bed

Format

Injectable

Purity

≥98%

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Overview

Sermorelin is GHRH(1-29), the first 29 amino acids of the 44-residue growth hormone releasing hormone your hypothalamus already makes. Truncating the sequence at residue 29 turned out to cost nothing: the fragment retains full biological activity at the pituitary GHRH receptor, which is why it became the reference GHRH analog rather than a curiosity. Ross and colleagues established that administering GHRH restores growth hormone output in deficiency states, work that put the molecule into clinical use [1]. Because it acts one level upstream of the pituitary rather than replacing the hormone outright, negative feedback and pulsatility both stay intact, and a functioning pituitary is required for it to do anything at all. In older adults, where GH output declines but the gland itself still responds, twice-daily GHRH(1-29) restored GH and IGF-1 toward young-adult levels [2], and single nightly injections timed to the natural sleep pulse produced measurable increases in healthy elderly men [3].

Sequence & properties

Sequence, colored by side chain

YADAIFTNSYRKVLGQLSARKLLQDIMSR
Basic (+)5Acidic (−)2Hydrophobic12Polar10

Length

29 aa

Avg mass

3,358.9 Da

Theoretical pI

10.44

Net charge (pH 7)

+3.0

Molecular formula: C149H245N43O43SSermorelin is the GHRH(1-29) C-terminal amide (about −1 Da). Values above are for the unmodified sequence.
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Mechanism

Binds GHRH receptors on pituitary somatotrophs, raising cAMP and triggering release of stored growth hormone. The endogenous version of this signal is what generates GH pulses in the first place: blocking it with a selective GHRH antagonist flattens the pulse pattern, which is direct evidence that the receptor sermorelin targets is the pulse generator [4]. That is the mechanistic reason protocols time administration to sleep onset. The largest natural GH pulse arrives during early slow-wave sleep, so dosing there amplifies an existing pulse instead of forcing an artificial one while the axis is quiet. Somatostatin tone still applies the brake, which is the built-in ceiling that exogenous growth hormone bypasses and sermorelin does not.

Researched benefits

  • Natural GH stimulation
  • Improved sleep architecture
  • Anti-aging research
  • Pediatric growth applications

Frequently asked

Sermorelin vs CJC-1295: what is the difference?

Sermorelin is native GHRH(1-29) with a half-life measured in minutes. CJC-1295 modifies that same sequence to resist enzymatic degradation, extending the half-life dramatically. Sermorelin produces a short, sharp pulse; CJC-1295 produces sustained elevation.

Why is sermorelin dosed before bed?

The largest natural GH pulse occurs during early slow-wave sleep. Bedtime administration is intended to amplify that existing pulse rather than create an artificial one at a time when the axis is normally quiet.

Sermorelin vs tesamorelin?

Both are GHRH analogs, but tesamorelin is a stabilized GHRH(1-44) with a longer half-life and a clinical record specifically in visceral fat reduction. Sermorelin is the shorter native fragment and has been studied mainly in growth hormone deficiency.

Does sermorelin still work if the pituitary is impaired?

No. Sermorelin depends on a functioning pituitary because it stimulates the gland to release its own stored growth hormone. It is not a substitute for exogenous GH where pituitary function is absent.

Scientific Literature

References

  1. [1]

    Ross RJ, Rodda C, Tsagarakis S, et al. (1987). Treatment of growth-hormone deficiency with growth-hormone-releasing hormone.

    Lancet · PubMed: 2879138

  2. [2]

    Corpas E, Harman SM, Piñeyro MA, et al. (1992). Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.

    Journal of Clinical Endocrinology & Metabolism · PubMed: 1379256

  3. [3]

    Vittone J, Blackman MR, Busby-Whitehead J, et al. (1997). Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.

    Metabolism · PubMed: 9005976

  4. [4]

    Jaffe CA, Friberg RD, Barkan AL. (1993). Suppression of growth hormone secretion by a selective GHRH antagonist: direct evidence for involvement of endogenous GHRH in the generation of GH pulses.

    Journal of Clinical Investigation · PubMed: 8349808

Citations are provided for educational purposes. Always verify primary sources before drawing research conclusions.

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