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NootropicNasalResearch Protocol

Semax Dosage Chart

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from a fragment of ACTH(4-10), developed in Russia and studied for nootropic and neuroprotective effects linked to BDNF modulation (Dolotov et al., 2006). The N-acetyl (amidate) variant is more potent per microgram.

AI-built tool. Cross-check critical values against authoritative sources before use.

Half-life

Short (minutes systemically; intranasal is standard)

Format

Nasal

Purity

≥99%

Protocols

3 variants

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Research Protocols

Dosage Protocols

Each row reflects a common research protocol variant. These are reference ranges derived from published literature and community research — not medical guidance.

Protocol 1

Standard Intranasal Protocol

2-8 weeks

Dose

300-600mcg daily, divided into 2-3 doses

Duration

2-8 weeks

Standard Semax intranasal research range. Split dosing accounts for the short half-life. N-acetyl Semax is dosed at the lower end of this range.

Protocol 2

Cognitive-Focused Protocol

2-4 weeks

Dose

600-900mcg daily, divided

Duration

2-4 weeks

Higher end used for focused cognitive research windows. Keep durations short and cycle off.

Protocol 3

Maintenance Protocol

Ongoing (cycled)

Dose

300mcg once daily

Duration

Ongoing (cycled)

Low daily dose after an initial phase. Often paired with Selank for a balanced nootropic-anxiolytic pairing.

Mixing Math

Reconstitution

Reference values for preparing a research vial. Adjust the syringe reading if you change the water volume.

Vial size

10mg vial (intranasal spray preparation)

BAC water

Reconstitute per compounding protocol into a nasal sprayer

Concentration

~300mcg per actuation (varies by fill volume)

Dose / ml

300mcg = one to two actuations depending on fill

Syringe units

N/A — intranasal, not injected

Need help converting different vial sizes? Use our reconstitution calculator to generate protocol-specific numbers instantly.

Storage

Handling Notes

Keep lyophilized vial cold (-20°C for long-term). Refrigerate the reconstituted nasal solution at 2-8°C and use within the compounder's stated window. Protect from light and heat.

Research Considerations

Cautions

  • Semax is a research compound not approved for human use in most jurisdictions. Source only COA-verified material.
  • Most clinical literature is Russian-language and uses the pharmaceutical intranasal formulation; potency of research-grade powder can vary.
  • N-acetyl Semax is more potent than plain Semax; do not swap them at the same microgram dose.

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Research use only. Not medical advice. Browse all dosage charts