EpithalonResearch guide
Tetrapeptide studied for telomerase activation and longevity
Half-life
~30 min
Typical Dose
5-10mg daily for 10-20 days, cycled
Format
Injectable
Purity
≥98%
Overview
Epithalon (Epitalon) is a synthetic tetrapeptide based on Epithalamin, a substance produced by the pineal gland. Russian research has studied it extensively for telomere length and lifespan effects.
Sequence & properties
Sequence, colored by side chain
Length
4 aa
Avg mass
390.3 Da
Theoretical pI
3.55
Net charge (pH 7)
-2.0
Mechanism
Stimulates telomerase enzyme activity, potentially extending telomere length. Also normalizes melatonin and cortisol rhythms via pineal action.
Researched benefits
- Telomerase activation in studies
- Pineal gland function support
- Sleep quality research
- Longevity applications
- Antioxidant effects
Frequently asked
What is epithalon's sequence?
Epithalon is the tetrapeptide Ala-Glu-Asp-Gly (AEDG), developed by Vladimir Khavinson as a synthetic analog of the pineal extract epithalamin. It is one of the short peptide bioregulators from that Russian research program.
What does the telomerase research actually show?
Telomerase activation has been reported in cell culture and in animal work from the Khavinson group. Independent replication in humans is limited, and claims about lifespan extension go well beyond what the published data support.
Why is epithalon cycled rather than dosed continuously?
Bioregulator protocols traditionally use short courses of 10 to 20 days repeated a few times per year, following the dosing pattern used in the original Russian studies rather than continuous administration.
Epithalon vs epitalon: which spelling is correct?
Both refer to the same AEDG tetrapeptide. Epitalon and epithalon are transliteration variants of the same Russian name, and the literature uses them interchangeably.
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Protocol
Epithalon dosage chart
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