MOTS-c
Mitochondrial-derived peptide for metabolic regulation and exercise capacity
Half-life
~4-6 hours
Typical Dose
5-10mg twice weekly
Format
Injectable
Purity
≥98%
Overview
MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA. Plays roles in metabolic homeostasis, insulin sensitivity, and exercise capacity. Considered a 'mitochondrial hormone.'
Sequence & properties
Sequence, colored by side chain
Length
16 aa
Avg mass
2,174.6 Da
Theoretical pI
10.64
Net charge (pH 7)
+3.0
Mechanism
Mitochondrial-encoded peptide that modulates AMPK activity and metabolic pathways. Increases glucose uptake and fat oxidation in skeletal muscle.
Researched benefits
- Improved insulin sensitivity
- Enhanced exercise capacity in studies
- Metabolic regulation
- Mitochondrial function support
- Anti-aging applications
Frequently asked
How do you reconstitute MOTS-c?
A 10mg vial reconstituted with 2ml of bacteriostatic water gives 5mg/ml. On a U-100 insulin syringe a 5mg research dose measures 100 IU (1ml) and 10mg measures 200 IU (2ml). Keep the reconstituted vial refrigerated at 2-8°C and use it within 14 to 30 days.
What is the typical MOTS-c research dosage?
Referenced research protocols commonly use 5 to 10mg subcutaneously twice weekly, with a 2 to 5mg daily microdose as an alternative pattern. The MOTS-c dosage chart breaks down standard, microdose, and loading protocols side by side.
Where can you buy research-grade MOTS-c?
MOTS-c is sold as a lyophilized research compound. Source only from suppliers that publish a third-party COA for each lot confirming identity and purity (≥98%). Ascension Peptides carries COA-verified MOTS-c and code ENHANCED takes 50% off.
What is the half-life of MOTS-c?
Roughly 4 to 6 hours. The short half-life is why both twice-weekly and daily microdose patterns appear in research protocols.
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