LL-37
Antimicrobial peptide for immune defense and wound healing research
Half-life
~30 min
Typical Dose
Research-dependent
Format
Injectable
Purity
≥98%
Overview
LL-37 is the only human cathelicidin, a 37-amino-acid antimicrobial peptide. Studied for its antimicrobial, immunomodulatory, and wound-healing properties.
Sequence & properties
Sequence, colored by side chain
Length
37 aa
Avg mass
4,493.3 Da
Theoretical pI
11.35
Net charge (pH 7)
+6.0
Mechanism
Disrupts microbial membranes through electrostatic and hydrophobic interactions. Also modulates immune cell recruitment and activation.
Researched benefits
- Broad-spectrum antimicrobial activity
- Immune modulation
- Wound healing
- Anti-biofilm effects
Frequently asked
What is LL-37?
LL-37 is the only human cathelicidin antimicrobial peptide, a 37-amino-acid fragment cleaved from the hCAP18 precursor. It is a component of innate immune defense found in neutrophils, epithelial cells, and skin.
How does LL-37 kill bacteria?
It is cationic and amphipathic, so it inserts into and disrupts negatively charged bacterial membranes. Because the mechanism is physical rather than enzymatic, resistance development is slower than with conventional antibiotics.
Does LL-37 do anything besides antimicrobial defense?
Yes. It is also chemotactic for neutrophils and monocytes, promotes angiogenesis, and modulates wound healing. These immunomodulatory roles are a large part of the current research interest.
Why is LL-37 not used systemically?
At higher concentrations it is cytotoxic to host cells as well as bacteria, and it is rapidly degraded by proteases in circulation. Research focuses on local and topical application rather than systemic administration.
Ready to start your research
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