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Thymosin Alpha-1

Immune-modulating peptide studied for immune support

Half-life

~2 hours

Typical Dose

1.6mg twice weekly

Format

Injectable

Purity

≥98%

Thymosin Alpha-1 research vial

Overview

Thymosin Alpha-1 is a peptide hormone naturally produced by the thymus gland. Studied for immune system modulation, infectious disease support, and adjuvant cancer research.

Sequence & properties

Sequence, colored by side chain

SDAAVDTSSEITTKDLKEKKEVVEEAEN
Basic (+)4Acidic (−)9Hydrophobic8Polar7

Length

28 aa

Avg mass

3,066.3 Da

Theoretical pI

3.99

Net charge (pH 7)

-5.0

Molecular formula: C127H213N33O54Thymosin α1 is N-terminally acetylated (about +42 Da). Values above are for the unmodified sequence.
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Mechanism

Stimulates differentiation of T-cell precursors and modulates innate and adaptive immune responses through Toll-like receptor activation.

Researched benefits

  • T-cell maturation support
  • Immune system modulation
  • Antiviral research
  • Adjuvant in oncology research

Frequently asked

What does thymosin alpha-1 do?

It is a 28-amino-acid peptide derived from prothymosin alpha that modulates immune function, primarily by supporting T-cell maturation and signaling through Toll-like receptors. It is an immune modulator rather than a direct antimicrobial.

Is thymosin alpha-1 an approved drug?

Yes, in a number of countries. It is marketed as Zadaxin and approved in over 30 countries for hepatitis B and C and as a vaccine adjuvant, though it is not FDA-approved in the United States.

Is thymosin alpha-1 related to TB-500?

Only by name. Thymosin alpha-1 and Thymosin Beta-4 are structurally unrelated peptides with different functions. Alpha-1 is immunomodulatory; Beta-4 is involved in actin regulation and tissue repair.

How is thymosin alpha-1 dosed?

Clinical protocols use subcutaneous injection, typically twice weekly, with the schedule set by indication. Its immune-modulating action does not require daily administration.

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