Calm + Clarity
PE 22-28 + Pinealon + Selank 30mg — the cognitive calm + focus stack
Price
$130
Compounds
3 peptides
Category
Cognitive
Format
Pre-Mixed Injectable
Overview
Calm + Clarity is a 30 mg cognitive stack combining PE 22-28, Pinealon, and Selank — three peptides with complementary mechanisms of action in the central nervous system. This stack targets researchers studying anxiolysis, cognitive clarity, and neuroprotection through a multi-pathway approach.
Selank is a synthetic analog of the immunomodulatory peptide tuftsin, developed at the Institute of Molecular Genetics (Russian Academy of Sciences). It modulates GABA-A receptor activity and has demonstrated anxiolytic effects comparable to benzodiazepines in animal models — without sedation, dependence, or cognitive impairment. Pinealon is a tripeptide (Glu-Asp-Arg) that has shown neuroprotective effects in cellular and animal models, particularly in oxidative stress conditions affecting CNS neurons.
PE 22-28 (also known as Spadin analog) is a short peptide that modulates TREK-1 potassium channels — a novel mechanism implicated in antidepressant and pro-cognitive research. Together, the three compounds address anxiety (Selank), neuroprotection (Pinealon), and mood/cognition (PE 22-28) through distinct receptor systems.
Why this combination works
The three compounds in Calm + Clarity target different receptor systems and neural pathways, creating a multi-target cognitive stack rather than a single-mechanism approach. Selank modulates GABAergic transmission for anxiolysis. Pinealon provides neuroprotective support through antioxidant and anti-apoptotic mechanisms at the cellular level. PE 22-28 modulates TREK-1 potassium channels — a mechanism distinct from both GABA modulation and traditional neuroprotection. The result is a stack that addresses the anxiety-cognition spectrum from three angles: calming overactive stress circuits (Selank), protecting neurons from damage (Pinealon), and promoting healthy baseline mood and cognitive function (PE 22-28).
What's inside
Selank
~30 min (intranasal) half-lifeTuftsin analog with anxiolytic effects via GABA-A receptor modulation. Reduces anxiety without sedation or cognitive impairment in animal models.
Pinealon
Short (tripeptide, rapid turnover) half-lifeNeuroprotective tripeptide (Glu-Asp-Arg) that protects CNS neurons from oxidative stress and supports healthy cellular function in the brain.
PE 22-28
TREK-1 potassium channel modulator with antidepressant and pro-cognitive properties in research models. A novel mechanism distinct from traditional anxiolytics.
Researched benefits
- Three-pathway approach to cognitive support: anxiolysis + neuroprotection + mood
- Selank: GABA modulation without sedation or dependence risk
- Pinealon: neuroprotective in oxidative stress models
- PE 22-28: novel TREK-1 channel modulation for mood and cognition
- Nasal-compatible peptides — non-invasive administration route
- 30 mg total volume for extended research cycles
Dosing & reconstitution
Research dosing
Research protocols typically use intranasal or subcutaneous administration. For intranasal delivery, standard protocols use 200-400 mcg per dose, 1-2 times daily. The pre-mixed ratio delivers proportional amounts of all three compounds per dose. Selank and Pinealon are well-suited to intranasal administration due to their CNS bioavailability through the nasal mucosa. Cycles vary from 2-4 weeks with breaks.
Reconstitution
For intranasal use: reconstitute with bacteriostatic water or sterile saline and transfer to a nasal spray bottle. For subcutaneous use: add 2 mL of bacteriostatic water and draw with an insulin syringe. The nasal route is most common for cognitive peptide stacks due to direct CNS access via the olfactory bulb.
Open reconstitution calculatorFrequently asked
Can this stack be used intranasally?
Yes — intranasal administration is the preferred route for many researchers studying cognitive peptides. Selank and Pinealon have demonstrated good bioavailability through the nasal mucosa, with direct access to the CNS via the olfactory pathway. Reconstitute with sterile saline and use a metered nasal spray bottle for consistent dosing.
Is Selank habit-forming like benzodiazepines?
Research to date has not shown dependence or tolerance development with Selank, despite its GABAergic mechanism. Unlike benzodiazepines, Selank modulates GABA-A receptors without the direct agonism that drives dependence. Animal studies show sustained anxiolytic effects without escalating dose requirements.
What is PE 22-28 and why is it less well-known?
PE 22-28 is a Spadin analog — a short peptide that modulates TREK-1 potassium channels in the brain. TREK-1 modulation is a relatively new area of neuroscience research (first characterized for antidepressant potential around 2010-2015), which is why it's less established than compounds like Selank. Early research is promising for mood and cognitive effects through a mechanism completely distinct from GABA or serotonin modulation.
Ready to start your research
Get the Calm + Clarity from Ascension Peptides
3 compounds, one vial, one reconstitution. COA-verified, US-based, discreet shipping. Use code ENHANCED for 50% off your entire order.
Buy Calm + Clarity — $130