5-Amino-1MQ
Selective NNMT inhibitor researched for fat loss, muscle preservation, and NAD+ salvage enhancement
Half-life
~8 hours
Typical Dose
50-150 mg daily
Format
Injectable
Purity
≥98%
Overview
5-Amino-1MQ is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme elevated in obesity and aged tissue. NNMT methylates nicotinamide (depleting the NAD+ salvage pool) and consumes SAM (methyl donor reserves). By blocking NNMT, 5-Amino-1MQ preserves NAD+ precursors and methyl donors, enhancing cellular energy balance and thermogenesis in adipose tissue without affecting appetite.
Mechanism
Selective small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase). NNMT normally methylates nicotinamide using SAM as the methyl donor, producing 1-methylnicotinamide and SAH. This depletes the NAD+ salvage substrate and consumes methyl donors. Inhibiting NNMT preserves nicotinamide for NAD+ recycling and restores cellular energy metabolism. In adipose tissue, this shifts the balance toward lipolysis and thermogenesis.
Researched benefits
- Fat loss without appetite suppression
- NAD+ salvage pathway preservation
- Muscle preservation during caloric deficit
- Increased energy expenditure
- Metabolic and body composition research
- Methyl donor (SAM) preservation
Frequently asked
How is 5-Amino-1MQ different from GLP-1 weight loss peptides?
GLP-1 agonists (Semaglutide, Tirzepatide, Retatrutide) drive fat loss primarily by reducing caloric intake via central satiety mechanisms. 5-Amino-1MQ works on the opposite side of the equation — it increases energy expenditure and fat oxidation in adipocytes without affecting appetite. The two mechanisms are complementary, and researchers often investigate them in combination.
Why does 5-Amino-1MQ also boost NAD+?
NNMT consumes nicotinamide, which is the main substrate the NAD+ salvage pathway uses to regenerate NAD+. When NNMT is overactive (as in obesity and aging), nicotinamide is diverted away from salvage. Blocking NNMT with 5-Amino-1MQ restores nicotinamide availability for the NAD+ pool — which is why it's often considered alongside direct NAD+ repletion strategies.
Why is muscle preservation claimed for 5-Amino-1MQ?
Published preclinical work reports that NNMT inhibition in the context of caloric deficit preserves lean mass better than caloric restriction alone, likely because improved NAD+ availability supports mitochondrial function and protein homeostasis in muscle tissue. Human data remain preliminary.
Injectable vs oral for 5-Amino-1MQ?
5-Amino-1MQ is a small molecule and has been investigated both orally and via injection. Injectable forms offer more predictable systemic exposure, while oral forms prioritize convenience. Ascension's current catalog offers the injectable presentation used in most research protocols.
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