TB-500 (Thymosin Beta-4)
Synthetic thymosin beta-4 fragment studied for muscle, tendon, and tissue regeneration
Half-life
~2-3 hours
Typical Dose
2-5mg twice weekly
Format
Injectable
Purity
≥98%
Overview
TB-500 is a synthetic version of an active region of Thymosin Beta-4, a naturally occurring peptide. Studied for accelerating wound healing, muscle recovery, and cardiac repair.
Sequence & properties
Sequence, colored by side chain
Length
43 aa
Avg mass
4,921.5 Da
Theoretical pI
4.72
Net charge (pH 7)
-2.0
Mechanism
Promotes actin polymerization, cell migration, and angiogenesis. Modulates inflammation and supports tissue repair across multiple cell types.
Researched benefits
- Muscle tissue repair
- Tendon and ligament healing
- Cardiac tissue regeneration research
- Hair growth in animal studies
- Anti-inflammatory effects
Wolverine Stack
BPC-157 10mg + TB-500 10mg — pre-mixed, research-ready
Partner price
$130
- Single vial, single reconstitution
- Proven 1:1 ratio from recovery protocols
- Same-day US shipping · COA verified
Code ENHANCED applies at checkout
GLOW Blend
GHK-Cu + BPC-157 + TB-500 — the complete recovery + skin stack
Partner price
$160
- Three proven compounds in one vial
- Covers skin, tissue repair, and systemic healing
- Premium formulation
Code ENHANCED applies at checkout
Frequently asked
Is TB-500 the same as Thymosin Beta-4?
Not quite. Thymosin Beta-4 is the full 43-amino-acid protein. TB-500 is the synthetic fragment containing the actin-binding domain, the region responsible for most of the cell migration and repair activity. The fragment is smaller and more soluble.
TB-500 vs BPC-157 for tissue repair?
They work through different mechanisms and are often studied together. TB-500 acts on actin polymerization and cell migration; BPC-157 drives angiogenesis and growth factor upregulation. The pairing is common precisely because the pathways do not overlap.
Why do protocols describe a loading phase?
TB-500 research protocols often front-load administration for the first several weeks, then reduce frequency. The rationale is reaching tissue saturation quickly before moving to a maintenance schedule.
What is TB-500's half-life?
Reported plasma half-life is short, but the actin-binding activity is thought to persist in tissue longer than plasma clearance alone would suggest, which is the basis for less frequent dosing schedules.
Ready to start your research
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