Weight Loss Peptides
The most actively researched category in modern peptide therapy. Includes GLP-1 receptor agonists like Semaglutide, dual agonists like Tirzepatide, and triple agonists like Retatrutide. These compounds have transformed weight management research with significant body composition outcomes.
Compounds
19
Most Studied
Retatrutide
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Researched compounds
All Weight Loss peptides
Retatrutide
Triple agonist (GLP-1 / GIP / Glucagon) researched for significant weight management effects
Half-life
~6 days
Purity
≥98%
Tirzepatide
Dual GIP/GLP-1 agonist studied for metabolic health and significant weight outcomes
Half-life
~5 days
Purity
≥99%
Semaglutide
GLP-1 receptor agonist for blood sugar management and weight reduction research
Half-life
~7 days
Purity
≥99%
Liraglutide
Once-daily GLP-1 receptor agonist (Victoza/Saxenda) for glycemic control and weight management
Half-life
~13 hours
Purity
Pharmaceutical grade (prescription drug)
Cagrilintide
Long-acting amylin analogue researched in combination with GLP-1 agonists
Half-life
~7 days
Purity
≥98%
AOD-9604
Modified hGH fragment (177-191) researched for lipolytic activity without growth effects
Half-life
~30 min
Purity
≥98%
Dulaglutide
Once-weekly GLP-1 receptor agonist (Trulicity) approved for type 2 diabetes, with modest weight loss as a secondary effect
Half-life
~5 days
Purity
Pharmaceutical grade (prescription drug)
5-Amino-1MQ
Selective NNMT inhibitor researched for fat loss, muscle preservation, and NAD+ salvage enhancement
Half-life
~8 hours
Purity
≥98%
Exenatide
The first-in-class GLP-1 receptor agonist, derived from Gila monster venom and now largely superseded by newer agents
Half-life
~2.4 hours (Byetta); once-weekly extended-release (Bydureon)
Purity
Pharmaceutical grade (prescription drug)
Survodutide
Investigational dual glucagon/GLP-1 receptor agonist studied for obesity and MASH liver disease
Half-life
~4 days (approx 100 hours)
Purity
≥98%
HGH Fragment 176-191
C-terminal fragment of human growth hormone (residues 176-191) researched for lipolysis without the growth, IGF-1, or glucose effects of full GH
Half-life
~20-30 min
Purity
≥98%
Pemvidutide
Investigational GLP-1 / glucagon dual agonist studied for obesity and MASH with strong lean-mass preservation
Half-life
~110 hours (about 4.6 days)
Purity
≥98%
Pramlintide
FDA-approved amylin analog (Symlin) injected at mealtimes as an insulin adjunct for glucose and weight control
Half-life
~48 min
Purity
Pharmaceutical grade (prescription drug)
Setmelanotide
MC4R agonist (brand Imcivree) FDA-approved to treat rare genetic obesity by restoring the impaired leptin-melanocortin satiety pathway
Half-life
~11 hours
Purity
Pharmaceutical grade (prescription drug)
Peptide YY
Gut satiety hormone (PYY 3-36) and Y2 receptor agonist studied for appetite suppression
Half-life
~8-30 minutes (short circulating half-life of PYY 3-36)
Purity
≥98%
Lixisenatide
Short-acting once-daily prandial GLP-1 receptor agonist for post-meal glucose control
Half-life
~3 hours
Purity
Pharmaceutical grade (prescription drug)
Ghrelin
The body's only circulating hunger hormone and the natural ligand every GHS-R agonist was built to mimic
Half-life
~30 min (acylated ghrelin); the des-acyl form persists longer
Purity
≥98%
Adipotide
Experimental prohibitin-targeting peptidomimetic (FTPP) that ablates the blood vessels feeding white fat. No human trials.
Half-life
Short; rapid plasma clearance, not characterized in humans
Purity
≥98%
Nesfatin-1
Anorexigenic peptide cleaved from NUCB2, researched for leptin-independent appetite suppression in rodents
Half-life
Not established in humans (rodent data only)
Purity
≥98%
01 — Overview
What are weight loss peptides?
The most actively researched category in modern peptide therapy. Includes GLP-1 receptor agonists like Semaglutide, dual agonists like Tirzepatide, and triple agonists like Retatrutide. These compounds have transformed weight management research with significant body composition outcomes.
02 — Mechanism
How do they work?
Each compound in this category targets a specific biological pathway — receptor agonism, enzyme modulation, or cellular signaling. The mechanisms drive both the benefits and the side-effect profile, so understanding them is essential before designing any research protocol.
03 — Considerations
What to consider
Source matters. Always verify Certificate of Analysis (COA), storage conditions, and reconstitution protocol. Cross-reference half-life with dosing frequency, and review existing clinical data before extrapolating between research models.
Frequently asked
Common questions
What are weight loss peptides?
Weight Loss peptides are a class of research peptides studied for specific biological pathways and outcomes. Each compound has its own mechanism, dosing protocol, and body of evidence. We curate the most-researched options on this page.
How do I choose between compounds in this category?
Compare mechanism of action, half-life, dosing convenience, and the depth of clinical or preclinical research. Click any compound below for a full guide including FAQs and a reconstitution calculator.
Where can I source research-grade weight loss peptides?
We partner with Ascension Peptides for third-party-tested, COA-verified peptides. Use code ENHANCED at checkout for 50% off any order.
Are these peptides legal?
Research peptides are sold for laboratory and educational purposes only. They are not approved for human use. Always comply with the laws of your jurisdiction.
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